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KMID : 0390219990100020217
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Journal of Clinical Otolaryngology, Head and Neck Surgery
1999 Volume.10 No. 2 p.217 ~ p.223
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Expression of CC Chemokine Receptor 3 mRNA in Human Nasal Polyps
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정환우/Hwan Woo Jung
박성호/이정훈/황찬승/양훈식/김춘길/Seng Ho Park/Jung Hoon Lee/Chan Seung Hwang/Hoon Sik Yang/Chun Gil Kim
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Abstract
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Background and Objectives : Nasal polyp ran be defined as a chrhonic inflammatory
disease of the paranasal sinus mucosa, histologically characterized by massive edema
and accumulation of eosinophils. Eosinophils in the inflammatory tissue release mediators
capable of causing tissue damage. The recruiment of eosinophils of the site of
inflammation are mediated by a number of chemokines, particularly eotaxin, RANTES,
MCP-3, MCP-4. The receptor that mediates these action has been known CCR3 which
are expressed highly on the surface of eosinophis. This study was designed to
determine whether there is increased expression of CCR3 in natal polyp and whether
this is associated with eosinophil count in histopathology.
Materials and Methods : We performed the light microscopic examination for
histopathology and the analysis of CCR3 mRNA with RT-PCR in 20 nasal polyps, 7
allergic inferior turbinate mucosas and 6 hypertrophic inferior turbinate mucosas.
Results : The number of eosinophil were higher in nasal polyps than in allergic
inferior turbinate mucosas and hypertrophic inferior turbinate mucosas. The expression
levels of CCR3 mRNA were higher in nasal polyps than in allergic inferior turbinate
mucosas and hypertrophic inferior turbinate mucosas. The Infiltrating eosiuophils were
correlated the expression levels of CCR3 mRNA(p<0.001, r=0.877).
Conclusion : These results suggesr that CCR3 is a host factors highly specialized far
eosinophil recruitment in inflammation, and may be good targets for the development of
selective drug for inflammatory disease where eosinophils contribute to pathogenesis.
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